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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1971 1
1978 1
1981 2
1982 2
1983 5
1984 9
1985 20
1986 40
1987 60
1988 125
1989 159
1990 184
1991 180
1992 191
1993 256
1994 243
1995 316
1996 293
1997 313
1998 301
1999 327
2000 321
2001 344
2002 312
2003 304
2004 257
2005 282
2006 295
2007 237
2008 263
2009 263
2010 257
2011 226
2012 211
2013 230
2014 189
2015 149
2016 168
2017 141
2018 160
2019 155
2020 141
2021 137
2022 100
2023 97
2024 41

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7,904 results

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The following term was not found in PubMed: AF6-88.5
Page 1
Site-directed mutagenesis by overlap extension using the polymerase chain reaction.
Ho SN, Hunt HD, Horton RM, Pullen JK, Pease LR. Ho SN, et al. Gene. 1989 Apr 15;77(1):51-9. doi: 10.1016/0378-1119(89)90358-2. Gene. 1989. PMID: 2744487
Using this technique of site-directed mutagenesis, three variants of a mouse major histocompatibility complex class-I gene have been generated, cloned and analyzed. ...
Using this technique of site-directed mutagenesis, three variants of a mouse major histocompatibility complex class-I gene have been …
Targeting the lipid kinase PIKfyve upregulates surface expression of MHC class I to augment cancer immunotherapy.
Bao Y, Qiao Y, Choi JE, Zhang Y, Mannan R, Cheng C, He T, Zheng Y, Yu J, Gondal M, Cruz G, Grove S, Cao X, Su F, Wang R, Chang Y, Kryczek I, Cieslik M, Green MD, Zou W, Chinnaiyan AM. Bao Y, et al. Proc Natl Acad Sci U S A. 2023 Dec 5;120(49):e2314416120. doi: 10.1073/pnas.2314416120. Epub 2023 Nov 27. Proc Natl Acad Sci U S A. 2023. PMID: 38011559 Free PMC article.
Genetic depletion or pharmacologic inhibition of PIKfyve elevated tumor-specific MHC-I surface expression, increased intratumoral functional CD8(+) T cells, and slowed tumor progression in multiple syngeneic mouse models. Importantly, enhanced antitumor responses by Pikfyv …
Genetic depletion or pharmacologic inhibition of PIKfyve elevated tumor-specific MHC-I surface expression, increased intratumoral functional …
Host MHC class I gene control of NK-cell specificity in the mouse.
Höglund P, Sundbäck J, Olsson-Alheim MY, Johansson M, Salcedo M, Ohlén C, Ljunggren HG, Sentman CL, Kärre K. Höglund P, et al. Immunol Rev. 1997 Feb;155:11-28. doi: 10.1111/j.1600-065x.1997.tb00936.x. Immunol Rev. 1997. PMID: 9059879 Review.
The missing self model predicts that NK cells adapt somatically to the type as well as levels of MHC class I products expressed by their host. Transgenic and gene knock-out mice have provided conclusive evidence that MHC class I …
The missing self model predicts that NK cells adapt somatically to the type as well as levels of MHC class I products e …
NLRC5: a newly discovered MHC class I transactivator (CITA).
Meissner TB, Li A, Kobayashi KS. Meissner TB, et al. Microbes Infect. 2012 Jun;14(6):477-84. doi: 10.1016/j.micinf.2011.12.007. Epub 2011 Dec 22. Microbes Infect. 2012. PMID: 22209772 Free PMC article. Review.
It has recently been discovered that another member of the NLR protein family, NLRC5, transcriptionally activates MHC class I genes, and thus acts as "CITA" (MHC class I transactivator), a counterpart to CIITA. In addition to MH …
It has recently been discovered that another member of the NLR protein family, NLRC5, transcriptionally activates MHC class …
NLRC5: a key regulator of MHC class I-dependent immune responses.
Kobayashi KS, van den Elsen PJ. Kobayashi KS, et al. Nat Rev Immunol. 2012 Dec;12(12):813-20. doi: 10.1038/nri3339. Nat Rev Immunol. 2012. PMID: 23175229 Review.
NOD-, LRR- and CARD-containing 5 (NLRC5) was recently identified as a specific transactivator of MHC class I genes (CITA). NLRC5 and the master regulator for MHC class II genes, class II transactivator (CIITA), interact with similar MHC promoter-bound …
NOD-, LRR- and CARD-containing 5 (NLRC5) was recently identified as a specific transactivator of MHC class I genes …
MHC class-I transgenic mice.
Arnold B, Hämmerling GJ. Arnold B, et al. Annu Rev Immunol. 1991;9:297-322. doi: 10.1146/annurev.iy.09.040191.001501. Annu Rev Immunol. 1991. PMID: 1910680 Review.
The introduction of cloned genes into the germline of mice has been proven to be a powerful tool to investigate the role of the respective gene products within the immune system. Here we summarize the transgenic mouse models that have been established with major his …
The introduction of cloned genes into the germline of mice has been proven to be a powerful tool to investigate the role of the respe …
MHC class I expression and synaptic plasticity after nerve lesion.
Thams S, Oliveira A, Cullheim S. Thams S, et al. Brain Res Rev. 2008 Jan;57(1):265-9. doi: 10.1016/j.brainresrev.2007.06.016. Epub 2007 Jul 27. Brain Res Rev. 2008. PMID: 17764750 Review.
Thus, when MHC class I signalling is severely impaired in mice lacking the MHC class I subunit beta2-microglobulin (beta2m) and transporter associated with antigen processing 1 (TAP 1) genes, both of which are necessary for surface …
Thus, when MHC class I signalling is severely impaired in mice lacking the MHC class I subu …
NLRC5-CIITA Fusion Protein as an Effective Inducer of MHC-I Expression and Antitumor Immunity.
Santharam MA, Shukla A, Levesque D, Kufer TA, Boisvert FM, Ramanathan S, Ilangumaran S. Santharam MA, et al. Int J Mol Sci. 2023 Apr 13;24(8):7206. doi: 10.3390/ijms24087206. Int J Mol Sci. 2023. PMID: 37108368 Free PMC article.
Aggressive tumors evade cytotoxic T lymphocytes by suppressing MHC class-I (MHC-I) expression that also compromises tumor responsiveness to immunotherapy. ...As the clinical application of NLRC5 is constrained by its large size, we examined whether a smaller …
Aggressive tumors evade cytotoxic T lymphocytes by suppressing MHC class-I (MHC-I) expression that also compromises tum …
Cloning, genome structure and expression analysis of MHC class I gene in Korean quail.
Zhao S, Cui X, Pang Y, Zhang X, You X, Yang Y, Lei Y. Zhao S, et al. Br Poult Sci. 2022 Jun;63(3):291-297. doi: 10.1080/00071668.2021.1991885. Epub 2021 Oct 25. Br Poult Sci. 2022. PMID: 34649479
However, avian MHC genetic structure is different from that of mammals. In this study, the structure and expression of Korean quail MHC class I gene was analysed.2. The quail MHC gene consisted of eight exons and seven introns. ...Exons 5 to 8 coded for conne …
However, avian MHC genetic structure is different from that of mammals. In this study, the structure and expression of Korean quail MHC …
Mouse MHC class I-like Fc receptor encoded outside the MHC.
Ahouse JJ, Hagerman CL, Mittal P, Gilbert DJ, Copeland NG, Jenkins NA, Simister NE. Ahouse JJ, et al. J Immunol. 1993 Dec 1;151(11):6076-88. J Immunol. 1993. PMID: 7504013
The nucleotide and predicted amino acid sequences of the two positive clones were very similar to those of rat FcRn. Comparison of the FcRn domains to various MHC class I and CD1 molecules suggests a divergence of FcRn from MHC early in the mammalian lineage. …
The nucleotide and predicted amino acid sequences of the two positive clones were very similar to those of rat FcRn. Comparison of the FcRn …
7,904 results